Tumor lysis syndrome

Cairo-Bishop Definition
1) Laboratory tumor lysis syndrome: abnormalitiy in two or more of the following and occurs within 3 days before or 7 days after chemotherapy.
a) uric acid > 8 mg/dL or 25% increase
b) potassium > 6 meq/L or 25% increase
c) phosphate > 4.5 mg/dL or 25% increase
d) calcium < 7 mg/dL or 25% decrease
2) Clinical tumor lysis syndrome: laboratory tumor lysis syndrome plus one or more of the following:
a) increase serum creatinine (1.5 times upper limit of normal)
b) cardiac arrhythmia or sudden death
c) seizure
(A grading scale (0-5) is used depending on the presence of lab TLS, serum creatinine, arrhythmias, or seizures.)