IRIS - Immune reconstitution inflammatory syndrome
Definition:
Worsening of preexisting infectious processes (ie: herpes zoster, TB, MAC, CMV, Cryptococcus) after initiation of HAART treatment secondary to re-activation of the immune system
Management:
- Treat underlying opportunistic infection
- Continue ART treatment unless patient is experiencing life-threatening IRIS requiring hospitalization, intubation, etc
- Consider prednisone (1 mg/kg/day with a 10-14 day taper) to decrease inflammatory response
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